B.E. Ford, S.S. Chachra, A. Alshawi, F. Oakley, R.J. Fairclough, D.M. Smith, D. Tiniakos, L. Agius. “Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants”. Biochem Pharmacol. 2024, Aug. 229:116499. PMID: 39173844. [ Full text] [ PDF] [ Data]
A.M. Buziau, M.H. Oosterveer, K. Wouters, T. Bos, D.R. Tolan, L. Agius, B.E. Ford, D. Cassiman, C.D.A. Stehouwer, C.G. Schalkwijk, M.C.G.J. Brouwers. “Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency”. Mol Metab. 2024, Jul. 87:101984. PMID: 38972375. PMCID: PMC11300931. [ Full text] [ PDF]
B.E. Ford, S.S. Chachra, K. Rodgers, T. Moonira, Z.H. Al-Oanzi, Q.M. Anstee, H.L. Reeves, J.M. Schattenberg, R.J. Fairclough, D.M. Smith, D. Tiniakos, L. Agius. “The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326”. Mol Metab. 2023, Jun. 72:101722. PMID: 37031802. PMCID: PMC10182400. [ Full text] [ PDF] [ Data]
B.E. Ford, S.S. Chachra, A. Alshawi, A. Brennan, S. Harnor, C. Cano, D.J. Baker, D.M. Smith, R.J. Fairclough, L. Agius. “Chronic Glucokinase Activator treatment activates liver Carbohydrate Response Element binding protein and improves hepatocyte ATP homeostasis during substrate challenge”. Diabetes Obes Metab. 2020, 22:1985–1994. PMID: 32519798. [ Full text] [ PDF] [ Data]
T. Moonira, S.S. Chachra, B.E. Ford, S. Marin, A. Alshawi, N.S. Adam-Primus, C. Arden, Z.H. Al-Oanzi, M. Foretz, B. Viollet, M. Cascante and L. Agius. “Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation”. J Biol Chem. 2020, Mar 6; 295(10): 3330-3346. Epub 2020 Jan 23. PMID: 31974165. PMCID: PMC7062158. [ Full text] [ PDF]
B.E. Ford, B. Sun, J. Carpino, E.S. Chapler, J. Ching, Y. Choi, K. Jhun, J.D. Kim, G.G. Lallos, R. Morgenstern, S. Singh, S. Theja and J.J. Dennehy. “Frequency and Fitness Consequences of Bacteriophage Φ6 Host Range Mutations”. PLoS ONE. 2014, Nov 19; 9(11): e113078. PMID: 25409341. PMCID: PMC4237377. [ Full text] [ PDF]
A. Rodríguez, K. Kleinbeck, O. Mizenina, L. Kizima, K. Levendosky, N. Jean-Pierre, G. Villegas, B.E. Ford, M.L. Cooney, N. Teleshova, M. Robbiani, B.C. Herold, T. Zydowsky, J.A. Fernández-Romero. “In Vitro and In Vivo Evaluation of Two Carrageenan-based Formulations to Prevent HPV Acquisition”. Antiviral Res. 2014; 108C, 88-93. PMID: 24909570. PMCID: PMC4116815. [ Full text] [ PDF]
L. Kizima, A. Rodríguez, J. Kenney, N. Derby, O. Mizenina, R. Menon, S. Seidor, S. Zhang, K. Levendosky, N. Jean-Pierre, P. Pugach, G. Villegas, B.E. Ford, A. Gettie, J. Blanchard, M. Piatak, J.D. Lifson, G. Paglini, N. Teleshova, T.M. Zydowsky, M. Robbiani and J.A. Fernández-Romero. “A Potent Combination Microbicide that Targets SHIV-RT, HSV-2 and HPV”. PLoS ONE. 2014; 9(4): e94547. PMID: 24740100. PMCID: PMC3989196. [ Full text] [ PDF]
J.A. Fernández-Romero, C. Abraham, A. Rodríguez, L. Kizima, N. Jean-Pierre, R. Menon, O. Begay, S. Seidor, B.E. Ford, P.I. Gil, J. Peters, D. Katz, M. Robbiani, and T. Zydowsky. “Zinc Acetate Formulated in Carrageenan Exhibits Potent Activity in vivo Against High Dose HSV-2 Vaginal and Rectal Challenge”. Antimicrob Agents Chemother. 2012 Jan; 56(1): 358-68. Epub 2011 Nov 7. PMID: 22064530. PMCID: PMC3256046. [ Full text] [ PDF]
O. Begay, N. Jean-Pierre, C. Abraham, A. Chudolij, S. Seidor, A. Rodríguez, B.E. Ford, M. Henderson, D. Katz, T. Zydowsky, M. Robbiani, and J.A. Fernández-Romero. 2011. “Identification of Personal Lubricants that can Cause Rectal Epithelial Cell Damage and Enhance HIV-1 Replication In Vitro”. AIDS Res Hum Retroviruses. 2011 Sep; 27(9): 1019-24. Epub 2011 Mar 8. PMID: 21309617. PMCID: PMC3161103. [ Full text] [ PDF]
B.E. Ford, M. Baloh, and J.J. Dennehy. Evolutionary ecology of the viruses of microorganisms. In Viruses of Microorganisms. Hyman P & Abedon ST (eds.). Poole, UK: Caister Academic Press; 2018. Chapter 3; p.53-76. vi + 374p. [ PDF]
L. Agius, S.S. Chachra, and B.E. Ford. “The protective role of the Carbohydrate response element binding protein in the liver: the metabolite perspective”. Front. Endocrinol. 2020, 11:594041. PMID: 33281747. PMCID: PMC7705168. [ Full text] [ PDF]
L. Agius, B.E. Ford, and S.S. Chachra. “The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective”. Int. J. Mol. Sci. 2020, 21(9), 3240. PMID: 32375255. PMCID: PMC7247334. [ Full text] [ PDF]